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22,23 Obese HFpEF patients have greater LV hypertrophy and pulmonary capillary wedge pressure, increased LV filling pressures and severe right ventricular dysfunction compared with non-obese HFpEF patients

20, the FDA stated that Zepbound, part of the GLP-1 receptor agonist medicines that include Ozempic, was cleared to treat moderate to severe OSA in individuals with obesity

135 It is noteworthy that MASLD patients exhibit diverse clinical characteristics, including biochemical markers, histology, and clinical outcomes due to varying body types, 136,137 which can lead to different treatment benefits