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PROVEN INTEGRITY
This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake
Researchers have known this for decades, which is why the field of peptide drug delivery exists in the first place
The decision to use GLP-1 receptor agonists should be based on their licensed indications (diabetes or obesity management) rather than cholesterol lowering alone, with lipid improvements considered a beneficial additional effect within a comprehensive cardiovascular risk reduction strategy
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