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In fact, low intake has been linked to increased risk of fracture and osteoporosis ( Research has found that vitamin C plays a critical role in bone formation, so a deficiency can increase the rate of bone loss ( Childrens skeletons may be especially affected by vitamin C deficiency, as they are still growing and developing ( Summary Vitamin C is important for bone formation, and deficiency can increase the risk of developing weak and brittle bones

Coelenterazine H (5 M) was then added to the plates and luminescence signals measured 1 h thereafter using an EnVision multilabel plate reader (PerkinElmer) at 18 s intervals before and after ligand addition (25 C)

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