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Switching to retatrutide Moving from a dual agonist (tirzepatide) to a triple agonist (retatrutide) is generally smoother because retatrutide maintains GLP-1 and GIP activation while adding glucagon receptor stimulation
In one study, at a maximum dose of 15 mg per week, tirzepatide led to a weight loss of about 20% after one year
Significant weight loss may unmask existing uterine conditionssuch as polyps or fibroidsthat can bleed
Glucose sensing in L cells: A primary cell study
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