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Briefly, the assay involves the enzymatic conversion of glucose to glucose-6-phosphate coupled with glucose-6-phosphate dehydrogenase, and the NADH thus formed reduces a colorless probe to a colorimetric product, which is then read at 450 nm
Mean body weight reduction reached approximately 24 percent at the highest dose tier a magnitude that, investigators have noted, exceeds the Phase 2 outcomes reported for dual GLP-1/GIP agonists at comparable trial durations (PMID 37366315)
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