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Patients should seek urgent medical attention for severe abdominal pain or allergic reactions, and report suspected adverse reactions via the MHRA Yellow Card scheme

The nausea is typically worst during the first two to four weeks at each dose level, then gradually fades as the body adapts

Clinical trials indicate that many patients achieve significant remission or symptom reduction

Orforgliprion caused an average 11% weight loss among overweight and obese people after a year and a half, researchers reported in the New England Journal of Medicine