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The comparison is not as simple as "newer is better." Each compound has genuine advantages the other lacks

Remember that obesity is a chronic disease, and long-term or even indefinite treatment may be the most appropriate approach for many individuals, just as ongoing medication is standard for other chronic conditions like hypertension or diabetes

[2] Adverse GI effects reported during spironolactone therapy include nausea, vomiting, cramping, diarrhea, gastritis, abdominal pain, gastric bleeding, and ulceration.2 Adverse nervous system effects that have been reported in patients receiving spironolactone therapy include headache, dizziness, drowsiness, lethargy, ataxia, and mental confusion

This effect causes angiogenesis, the growth of new dermal papilla cells