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High hepatic fat content is the important inducement of the impairment of redox imbalance and insulin resistance
Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction
However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH
Together these data indicate that P5 has superior antihyperglycaemic efficacy compared with Ex4 in hyperglycaemic ob/ob mice as well as in insulin-resistant DIO mice
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