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Lab studies and animal results often do not translate directly to real patients
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As a class, however, these agents work similarly where they mimic the structure of GLP-1 in vivo , and thus, can bind the GLP-1R, but are not subject to degradation by DPP-4
A review of 10 clinical studies found that caloric intake is reduced by 16 to 39 percent in adults treated with a GLP-1 receptor agonist or GIP/GLP-1 receptor agonist [1], and this may result in a reduced intake of protein, micronutrients, fiber, and fluids
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