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Hypoglycemia was reported in approximately 10% of cases, but no causal association with metformin has been established

A specific role for IGF-1 receptor (IGF-1R) signaling in the mediation of mammalian longevity was first established in IGF-1R haploinsufficient mice, which lived 33% longer than controls, but unlike other models of reduced somatotropic signaling, this effect was female specific 6

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Those averaging under 50 ounces accounted for three hospitalizations for dehydration and two for acute kidney issues