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Once participants arrived, they were given a snack (Clif-Bar, Indianapolis, USA) to standardize caloric intake and ensure a similar gastric content prior to alcohol administration
As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively
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