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These include botany, morphology, microscopy, high-performance thin-layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), liquid chromatography with mass spectrometry (LC-MS), inductively coupled plasma mass spectrometry (ICP-MS) for heavy metals testing, spectrophotometric methods (UV-Vis, FTIR), testing for microbial contamination, and other standard scientific methods

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But smart design and long-term human safety data are two different things, and we don't have the latter yet

Effect of weight reductions on estimated kidney function: Post-hoc analysis of two randomized trials