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At the same time, obesity can lead to irregular periods or heavier periods
However, there is no clear evidence of cumulative toxicity or safety in long term users of PD-1/PD-L1 inhibitors [11]
The process flow is simple, see figure 4
Precautions and not-recommended situations include history of pancreatitis, severe gastroparesis or other serious gastrointestinal disease, pregnancy/lactation (discontinue before conception), and type 1 diabetes
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