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GLP-1 is able to stimulate cAMP formation in RIN 1046-38 cells, which in turn causes an increase in insulin mRNA levels and insulin release, and insulin accumulation in the culture fluid was observed by adding GLP-1 (7-37) to RIN 1046-38 cells for 1 h incubation (Mojsov et al., 1987)

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Implications for clinical practice The increasing prescription rates of AOM semaglutide among adolescent may reflect a shift towards pharmacological interventions in managing pediatric obesity

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