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While such compounds have been described, none have yet been considered credible pharmacological candidates (253, 254) due to a combination of factors, including insufficient potency, lack of specificity of binding to the GLP-1R and suboptimal half-life

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Accordingly, PASC could be described as a SARS-CoV-2-induced chronic and self-perpetuating comprised state of m- Dys, where OxS potentially drives inflammation and shifts energy metabolism towards glycolysis while down-regulating OXPHOS 27,142,143

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