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No longer regarded merely as a consequence of mechanical wear and tear, OA is now conceptualized as a complex, whole-joint disease characterized by progressive degeneration of articular cartilage, subchondral bone remodeling, synovial inflammation, and alterations in surrounding peri-articular structures (Figure 1)
Injecting into lipohypertrophic tissue reduces drug absorption, creating unpredictable pharmacokinetics that undermine the very stability microdosing aims to achieve
Many people are most sensitive in the day or two after an injection
The drug can help people stay fuller for longer, leading to reduced caloric intake and potentially dramatic weight loss results
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