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(Right) GLP-1 receptor agonist (GLP-1RA) reduces cholesterol accumulation by affecting the expression of genes in the hepato-enteral circulation and cholesterol reverse transport pathway, such as farnesoid X receptor (FXR), fibroblast growth factor-15 (FGF15), fibroblast growth factor receptor 4 (FGFR4), cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), proprotein convertase subtilisin/kexin type 9 (PCSK9), low-density lipoprotein receptor (LDLR), etc
Sci Transl Med 10(472):eaat3392 Jun LS, Millican RL, Hawkins ED, Konkol DL, Showalter AD, Christe ME, Michael MD, Sloop KW (2015) Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production
About 69.1% of semaglutide-treated participants achieved 10% weight loss compared with 12% on placebo
4 Ferroptosis in recurrent miscarriage A variety of pathophysiological mechanisms contribute to RM, including genetic, anatomical, hormonal, and immunological factors
