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As we age the cellular NAD + levels decline in part due to the reduced expression of one of the enzymes of NAD + salvage, nicotinamide phosphoribosyl transferase (NAMPT) as well as due to increased NAD + degradation via increased activity of the NAD + and NADP + hydrolyzing enzyme, CD38

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Here, as expected, co-treatment with sulforaphane strongly reversed rotenone-inhibited phosphorylation of mTOR, p70S6K and 4EBP1 (Fig