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The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus

However, as previously reported, some phytochemicals increase the activity of L-glutamate decarboxylase (L-GAD), an enzyme responsible for the conversion of L-glutamate to GABA, and therefore, the level of GABA increases in the brain, especially in the hippocampus which leads to the activation of inhibitory pathway and help in the control of seizure (Kandeda et al., 2021a)