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Patients should be counseled to report severe abdominal pain (potential pancreatitis), right upper quadrant pain (possible gallbladder disease), visual changes (especially with diabetic retinopathy), persistent nausea or vomiting, or signs of dehydration which may increase risk of acute kidney injury
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Injection Site Reactions: Itchiness, redness, or pain at the injection site (for injectable medications)
[8] With rapamycin, inhibition of mTOR is due to the binding of rapamycin to the FK506 binding protein (FKBP12), which allosterically inhibits mTORC1
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