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Across 2,783 participants, GLP-1RAs were associated with: - Higher rates of MASH resolution without worsening fibrosis - Reduced liver fat and improved ALT, AST, and GGT levels - Significant decreases in body weight, BMI, waist circumference, HbA1c, and triglycerides While gastrointestinal side effects (nausea, vomiting, diarrhea) were more common, the overall benefit profile was substantial
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Tirzepatide is not currently authorized by Health Canada for obstructive sleep apnea, despite a 2024 US FDA approval for that indication
In this cohort study, most patients with overweight or obesity discontinued GLP-1 RA therapy within 1 year, but those without type 2 diabetes had higher discontinuation rates and lower reinitiation rates, the researchers concluded
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