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If you follow a vegetarian or vegan diet, you may have to seek alternative sources of B12 like tablets or the B12 injection to ensure you have the required levels of B12 to prevent deficiency

B12 injections: Intramuscular injections of vitamin B12 is one of the most common forms of administration, but it must be done by a medical professional (Shipton, 2015)

Any switch should be clinician-directed

Best for: People sensitive to methyl-B12 Those with histamine intolerance or mast cell issues Overmethylators or those with anxiety from methylated vitamins Detoxification support (binds to toxins like cyanide and nitric oxide) Balanced, gentle B12 support Advantages: Body controls conversion rate (less likely to cause overmethylation) Supports detoxification pathways Well-tolerated by most people Longer-lasting in the body than methyl-B12 Potential downsides: Requires conversion (may be less efficient with severe MTHFR mutations) Slightly less direct methylation support than methyl-B12 Can be harder to find in supplements Typical dosage: 1000-5000mcg daily 3