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Therefore, 120 Wistar male rats housed in SPF conditions were selected for this study

Body weight dropped by an average of 10 pounds

Operant discrimination training Next, discrimination training began in daily training sessions (M-F) where either 2 g/kg of a 20% alcohol solution (v/v) or a volume-equivalent amount of water was administered (i.g.)

Although the intraperitoneal administration of exendin 939 did not cause adverse hyperthermia effects, a critical aspect of developing TRPV1 antagonists is minimizing interference with TRPV1 activation by protons and hence identifying mode-selective antagonists 32