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Predictors of trimodality therapy and trends in therapy for malignant pleural mesothelioma

Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

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doi: 10.4161/cc.29338 73 RossiSGranerEFebboPWeinsteinLBhattacharyaNOnodyTet al