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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)
Tumor-initiating cells: a criTICal review of isolation approaches and new challenges in targeting strategies
10.1016/j.arcmed.2021.05.005 67 LiX.LiZ.DongX.WuY.LiB.KuangB.et al (2023)
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