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Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation
Results are sustainable when paired with behavior changes
Patients receiving the 2.4 mg weekly dose (Wegovy) for weight management may experience more pronounced digestive effects compared to those on lower doses used for diabetes management
According to the CDC, as of 2021, 38.1 million adults (14.7%) in the United States had diabetes, with the incidence increasing with age
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