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Across clinical trials, about 10% of patients see little to no weight loss with GLP-1 medication, Dr
The associated expenditures have been substantial: in 2022, the total annual cost of diabetes was $412.9 billion, and obesity-related medical costs in the US were estimated to be nearly $173 billion in 2021
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Current guidelines do not recommend combination therapy with GLP-1 RAs and DPP-4 inhibitors, and the ADA/EASD consensus report specifically recommends discontinuation of DPP-4 inhibitors when initiating GLP-1 RA therapy
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