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This age-related reduction correlates with decreased tissue repair capacity and is hypothesised to contribute to age-related hair thinning and follicle miniaturisation
It is also investigated in oxidative stress and cellular defense pathways, where it helps model how peptide signaling interacts with antioxidant systems and metabolic regulation
Agm antidepressant effects have been reported to depend upon both imidazoline and GABA receptors, and NMDA-NO axis inhibition (and less consistently between studies, perhaps also serotonin and adrenergic receptors), suggesting a complex ketamine-like rapid antidepressant mechanism that may involve Agm/Glu co-transmission (Uzbay, 2012
In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects
