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This, in turn, promotes the autoproteolytic activation of caspase-1, leading to the secretion of proinflammatory cytokines and the cleavage of gasdermin D, thereby inducing pyroptosis [225]

Tumor progression into soft tissues, lymph nodes or distant metastatic sites have been shown to dramatically reduce 5-year overall survival in patients with PTC, highlighting the need for a novel therapeutic approach for highly aggressive forms of PTC 6

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