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The ATF3 enhances the ferroptosis induced by erastin via the repression of system xc- (53), whereas AMP-activated protein kinase (AMPK)mediated beclin 1 (BECN1) phosphorylation increases ferroptosis by directly inhibiting system xc- activity (54)
Pyroptosis can activate tumor suppressor genes such as p53, which not only promotes the apoptosis of tumor cells but also inhibits the growth of TNBC [89]
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