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69 Conversely, the extracellular release of decorin (DCN, an extracellular matrix-derived damage-associated signaling proteoglycan), 70 high mobility group box 1 (HMGB1, an architectural DNA-binding factor in the cell nucleus), 71 and nuclear receptor coactivator 4 (NCOA4, a mediator of ferritinophagy) 72,73 may function as damage-associated alarm signals that promote inflammatory responses in the local microenvironment

Who Should Avoid BPC-157 Individuals with the following characteristics should avoid BPC-157 outside research contexts: Active cancer diagnosis or cancer history Family history of malignancy or genetic cancer predisposition (BRCA mutations, Lynch syndrome) Pre-malignant lesions or conditions (Barretts esophagus, high-grade dysplasia) Unscreened individuals past recommended cancer screening ages Pregnant or breastfeeding women should avoid BPC-157 due to absent safety data in these populations