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doi:10.4314/ajtcam.v8i5S.9 Kulkarni SK, Dhir A

Contributing Factors Beyond Weight Loss Several factors compound the hair loss risk during GLP-1 treatment: Reduced caloric intake Decreased appetite means fewer nutrients for hair follicle metabolism Protein insufficiency Hair is 95% keratin protein

For de novo NADPH synthesis pathway, correlation studies have revealed that thionicotinamide adenine dinucleotide (NADS) and thionicotinamide adenine dinucleotide phosphate (NADPS), converted from the pro-drug thionicotinamide (TN), act as inhibitors of NADKs through targeting the NAD-binding site of NADKs and decreasing the levels of NADPH