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It does this by releasing chemicals in the brain that help regulate appetite

Serious but Rare Risks GLP-1 medications can aggravate or trigger severe pancreatic inflammation in some patients. Both oral and injectable GLP-1 medications may cause gallbladder disease, and in rare cases involving patients with relevant risk factors, there have been associations with thyroid changes observed in animal studies. A serious allergic reaction is possible but uncommon

This function is defective in type 2 diabetes [7,8,9], presumably because DPP-4 activity is enhanced in patients with glucose intolerance [9,10,11]

These drugs do not work without significant lifestyle changes