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While the body can synthesize L-carnitine, certain populationslike older adults, vegetarians, vegans, and those with specific health conditionsmay experience deficiencies

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Ion transport mechanisms, including the plasma membrane Ca 2+ ATPase (PMCA) and anion exchanger 1 (AE1, Band 3), also function as checkpoints: PMCA extrudes excess Ca 2+ to limit overload, with its activity modulated by ceramide or AA, while AE1 mutations disrupting ion balance promote eryptosis (Nicolay et al., 2008