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During T-cell signaling, it must be reduced in order for the TCR/MHCII/CD4 receptor complex to form: a process that requires CD4 dimerization and domain swapping (Cerutti et al., in vitro (Gallina et al., in vivo (Cerutti et al., The phylogenetic tree for CD4, built from 51 sequences from 50 species is shown in Figure 2A

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