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Parenteral thiamine can in rare instances trigger an acute allergic response characterized by hypotension, breathlessness, itching, and swelling

SARS-CoV-2 invades cells by binding to ACE2, which leads to downregulation of ACE2 and feedback increased Ang II in the circulation, thus triggering NOX activation, resulting in oxidative stress and inflammation (Hikmet et al., 2020)

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In light of evidence from animal models that brain GSH concentrations peak in the morning, 46 the single study visit was scheduled at 0700 hours for each participant in an attempt to control for circadian fluctuations