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As a result, most oral forms of glutathione will not achieve the desired effects [78]

Together, these agents collectively influence serotonergic, dopaminergic, and noradrenergic transmission, brain-derived neurotrophic factormediated plasticity, inflammatory cascades, oxidative stress, and mitochondrial bioenergetics, pathways that are increasingly recognized as interdependent in the pathophysiology of depression (23)

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Cell Mol Biol Lett 27(1):33 Karpisheh V, Afjadi JF, Afjadi MN, Haeri MS, Sough TSA, Asl SH et al (2021) Inhibition of HIF-1/EP4 axis by hyaluronate-trimethyl chitosan-SPION nanoparticles markedly suppresses the growth and development of cancer cells