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Concomitant medicines and underlying conditions: Certain medicines including corticosteroids, some antipsychotics, and some antidepressants can increase appetite independently of retatrutide

Based on clinical trial exclusion criteria and similar medications, these compounds should be avoided by people with personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, history of pancreatitis, severe gastrointestinal disease, or those who are pregnant or breastfeeding

Individuals with absorption issues, such as those with gastrointestinal disorders or certain genetic conditions, may not benefit from oral supplements

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