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Local resolution was estimated for each reconstruction using the RELION implementation of local resolution algorithm 35 , and locally scaled maps were used for model building and refinement in all cases
They are particularly beneficial for older adults and those with conditions that impair B12 absorption
In silico molecular docking further supports this, showing that Epitalon has a high binding affinity for specific histone subtypes, H1/3 and H1/6, which play a regulatory role in chromatin compaction and accessibility [4]
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