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doi: 10.1186/s13099-024-00633-9 120 LiD.LiZ.WangL.ZhangY.NingS
While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes along with dietary sources of carnitine from protein-rich red meat, for example dietary supplementation of carnitine may pose benefits in certain physiological conditions
Importantly, the enzymatic activity of TETs is regulated by 2-oxoglutarate (2OG) as a cofactor and suppressed by metabolites such as 2-hydroxyglutarate (2HG) as a competitor of 2OG
Alternatively, continue daily injection at a reduced dose of 0.5 to 1mg
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