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Reduced FH enzyme activity leads to the accumulation of the cellular level of fumarate, and fumarate can undergo a reaction with cysteine residues of proteins, which is called succination (Pollard et al., 2005)
Materials and methods Primary hepatocytes and cell culture Cdo1-null ( Cdo1 / ) and wild-type ( Cdo1 + / + ) mice for this study were generated by crossing C57BL/6 Cdo1 + / male and female mice as described previously (Jurkowska et al
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Mulloy JC, Cancelas JA, Filippi MD, Kalfa TA, Guo F, Zheng Y
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