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Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model
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Also approved under the CNPV pilot, Foundayo is a once-daily, oral nonpeptide GLP-1 that requires dose titration to mitigate gastrointestinal side effects
1 Introduction Type 2 diabetes mellitus (T2DM) is a chronic hyperglycemia-induced metabolic disease ( Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)
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