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This effect arises from appetite suppression, increased fullness, and slower stomach emptying, which makes it easier to reduce caloric intake sustainably

See the related Commentary at Should GLP-1 receptor agonist therapy be used to treat obesity in Bardet-Biedl syndrome?.

This elevation in NAD+ levels activates critical metabolic pathways including SIRT1 (sirtuin 1), a longevity-associated protein that regulates insulin sensitivity, mitochondrial function, and cellular stress resistance

Pannacciulli N, Bunt JC, Koska J, Bogardus C, Krakoff J: Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans