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Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

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At present tissue based HA studies have limitations dues to availability of sample

Quite remarkably, in those with low POP levels, the typically robust association between diabetes and obesity was not observed in a nested case-controlled study, suggesting that obesity may exaggerate the metabolic disturbances caused by POPs (perhaps because adipose tissue provides a reservoir for fat-soluble toxins), rather than being directly responsible for the altered metabolism