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Overall, our results involving alterations in glutamatergic signaling in DAT-males suggest a downregulation of both pre- and postsynaptic processes, which could correlate with age-related deficits in cognitive and behavioral responses (Castillo-Vazquez et al., 2024), and were not as prominent in DAT-females (GSE295369)
March 2026: Novo Nordisk reported top-line REDEFINE-1 Phase 3 CagriSema data showing 22.7% mean body weight reduction at 52 weeks , demonstrating superiority over standalone semaglutide 2.4mg and confirming the semaglutide-plus-amylin combination as clinically competitive with tirzepatide
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