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Research using older generations of anti-obesity medication indicated that individuals with both obesity and diabetes faced greater challenges in achieving weight loss (46)
But MariTide, which is Amgen's GLP-1 drug, only needs to be taken once a month
The inactivation of GLP-1 and GIP by DPP-4 is the reason that the circulating half lifes of active (intact) GLP-1 and GIP are very short, since this degradation pathway is the main clearance pathway for GLP-1 and GIP
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