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Morbid obesity in PWS leads to increased risk of cardiopulmonary compromise, type 2 diabetes mellitus (DM), chronic leg edema, premature cardiovascular disease, and death [1,2]

Skin aging is characterized by decreased mitotic activity, disfunction of the skin barrier and reduced production of collagen and elastin fibers

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Aversion therapy, which involves using unpleasant stimuli to discourage certain behaviors, is not covered due to concerns about its effectiveness and ethical considerations in the treatment of addiction