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418 Bipolar disorder (BP) Both the total number of glial cells and astrocytic densities are substantially (up to 40%) decreased in the post-mortem BP tissues, whereas numbers of neurones are not changed
mTORC1 maintains granuloma structure, while JAK/STAT enhances cytokine production and immune cell activation, they suppress macrophage autophagy and promote formation of multinucleated giant cells, a hallmark of sarcoid granulomas (48)
Intestinal permeability, inflammation and the role of nutrients
One Phase 2 trial of lixisenatide in Parkinsons did meet its primary motor endpoint, the biology of GLP-1 in the brain is real, and questions remain about earlier intervention, specific subpopulations, and whether vascular or metabolic contributions to neurodegeneration might still respond
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