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Pathak treated an atherosclerotic mouse model with iodomethylcholine (IMC), a mechanism-based inhibitor of choline TMA lyase, and the loss of neutral sterols in mice feces was identified in the form of coprostanol (a bacterial metabolite of cholesterol) (83)
OBM Hepatol Gastroenterol
AANAT gene expression and phosphorylation become impaired
The peak area ratio of analyte to its internal standard was converted to a concentration using a 1/ x weighted linear fit calibration curve (58)
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