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Another aspect of the present invention relates to an anion exchange chromatography process for purifying a GLP-1 peptide from a mixture comprising said peptide and related impurities, comprising the step of: separating said GLP-1 peptide and said related impurities of said mixture by elution in a solution consisting essentially of an organic modifier, water, optionally a salt component, and optionally a buffer, with a linear or step gradient or isocratically in salt component and/or with a linear or step pH-gradient or at a constant pH-value, wherein the pH-gradient or pH-value should be in the range where said peptide has a negative local or overall net charge different from the local or overall negative net charge of said related impurities so as to remove said related impurities

Interestingly, combining the two treatments delivered even better results, with improved clinical outcomes and fewer dropouts in the combination group

Start your intake How Semaglutide and Bupropion Work in the Body Semaglutide activates GLP-1 receptors in the brain and pancreas, slowing stomach emptying and reducing hunger signals

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